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Changing from Helium to Nitrogen and Maintaining the Separation Efficiency in the Same Analysis Time

For several reasons, there is interest in replacing helium with a different carrier gas in gas chromatography. Hydrogen is the obvious choice, but there is concern about safety and reactivity. It is also possible to use nitrogen, but this is often not considered because it has a low optimal flow and velocity. Here, we will show that it is possible to replace helium with nitrogen as the carrier gas while separation, peak elution order, analysis time, response, and even oven temperature conditions can be kept the same.
Content previously published on www.sepscience.com.

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